Infant dietary exposure to dioxin-like polychlorinated biphenyls (dlPCBs), polybrominated and mixed halogenated dibenzo-p-dioxins and furans (PBDD/Fs and PXDD/Fs) in milk samples of lactating mothers in Accra, Ghana

In this study, polybrominated and mixed halogenated dibenzo-p-dioxins furans (PBDD/Fs PXDD/Fs), dioxin-like polychlorinated biphenyls (dlPCBs) were quantified in 24 human milk samples of first-time lactating mothers from Greater Accra region Ghana. The aims the study to determine concentrations toxic equivalent PBDD/F, PXDD/F dlPCBs milk, estimate an infant's daily intake. analysed for 12 PCBs, 7 congeners 2,3,7,8-polybrominated (PBDD/Fs), 2,3,7,8-mixed dioxins (PXDD/Fs, where X = Br/Cl). mean ranged 0.15 212.9 pg/g lipid dlPCB (mean TEQ: 1.67 pg WHO2005-TEQ/g lipid). Lesser 2,3,7,8-PXDD/Fs (and PBDD/Fs congeners) between <0.01-1.67 lipid, with a total tentative TEQ 0.56 lipid. For infant average weight kg, consuming estimated volume 600 mL intake 21 was 4.95 TEQ/kg bw/day; contributions dlPCBs, PXDD/Fs resulted 6.56 bw/day. results obtained although lower than dietary estimates industrialized countries, exceeded recommended safety standards 1 bw/day 1-4 Agency Toxic Substances Disease Registry (ATSDR) World Health Organization (WHO), respectively.